official website and that any information you provide is encrypted 1. Pityriasis rosea and pityriasis rosea-like eruption after anti-SARS-CoV-2 vaccination: a report of five cases and review of the literature. Bethesda, MD 20894, Web Policies Unauthorized use of these marks is strictly prohibited. Bethesda, MD 20894, Web Policies 10.1007/S11356-020-12070-7 Tina Burke, 40, a nurse who works on the oncology floor at Massachusetts General Hospital (MGH), received her first coronavirus shot on Jan. 3. It is believed to represent a delayed reaction to viral infections and is usually associated with endogenous systemic reactivation of human herpesvirus (HHV) 6 and / or 7 (1). Veraldi S, Boneschi V, Cusini M, Maronese CA. Dermatol Ther. It often presents with diffuse and confluent severely pruritic dusky-red erythematous lesions in the absence of herald patch (11). government site. Only some cases of PR/pityriasis rosealike eruption (PRLE) after anti-SARS-CoV- 2 vaccination have been reported.1-18 In the period May 2021-February 2022 we observed five cases of clinically typical PR that appeared after anti-SARS-CoV-2 vaccination with BNT162b2 (3 patients) or mRNA-1273 (2 patients). Then you may get smaller spots that sweep out from the middle of the body in a shape that looks like drooping pine-tree branches. 2022 Sep;21(9):3692-3703. doi: 10.1111/jocd.15209. Pityriasis rosea and pityriasis rosea-like eruption after anti-SARS-CoV-2 vaccination: a report of five cases and review of the literature. 2021;23(3):221228. 2022 Jul 6;15(1):9503. doi: 10.4081/dr.2022.9503. Epub 2022 Jan 31. Int J Dermatol. Please enable it to take advantage of the complete set of features! Variable dermatological manifestations including acral erythema, urticaria, vasculitis, vesicular or pustular eruptions, maculopapular rash have all been reported during the course of COVID19. 2021 Aug;185(2):e34. PRISMA, preferred reporting items for systematic reviews and metaanalysis. doi: 10.1002/iid3.804. Federal government websites often end in .gov or .mil. (2017) 9:7399. doi: 10.4081/dr.2017.7399, 17. 15 Pityriasis rosea and COVID19 S. Veraldi, C. Spigariolo Medicine Journal of medical virology 2020 2023 Mar 29;13(7):1286. doi: 10.3390/diagnostics13071286. 1. Would you like email updates of new search results? It's easily mistaken for scalp psoriasis and vice versa. We speculate that PR could be a delayed skin manifestation of COVID-19 infection, triggered either by SARS-CoV-2 immediately or indirectly by the reactivation of other viruses such as HHV-6 or HHV-7. National Library of Medicine Bethesda, MD 20894, Web Policies In our study we observed 2 cases of EM after covid19 vaccine , one occurred after the BBIBP-CorV vaccine while the other was observed after ChAdOx1 nCoV- 19 vaccine. Pearls and pitfalls: Adverse cutaneous reactions after COVID-19 vaccination. Pityriasis rosea and pityriasis rosea-like eruption after anti-SARS-CoV-2 vaccination: a report of five cases and review of the literature. doi: 10.1111/jdv.17342. The site is secure. Reply to "the significance of investigating clinical, histopathologic and virological features in pityriasis rosea and pityriasis rosea-like eruptions following COVID-19 vaccinations" by Ciccarese G. et al. doi: 10.1111/bjd.20143. Akdas E, Ilter N, Ogut B, Erdem O. Pityriasis rosea following CoronaVac COVID-19 vaccination: a case report. -, Welsh E, Cardenas-de la Garza JA, Cuellar-Barboza A, Franco-Marquez R, Arvizu-Rivera RI. doi: 10.1111/j.0022-202X.2005.23719.x. doi: 10.1111/dth.13878, 10. J Eur Acad Dermatol Venereol. doi: 10.1002/iid3.804. No HHV-6 and HHV-7 reactivation is detected. Epub 2022 Jan 5. They are described as small, itchy blisters found on the trunk of the body and filling with blood, present in middle-aged patients. (2021). [Epub ahead of print]. 8600 Rockville Pike Data were independently extracted and accessed for bias. The third type of rash, known as Covid fingers and toes (sometimes described as chilblains), is where red and purple bumps appear on the fingers or toes.. Once a person has pityriasis rosea, it rarely recurs. Additionally, differences in incidence of this reaction after Pfizer and Moderna vaccination may suggest a differing host immune response incited by these vaccines which warrants further investigation. Itching is often mild. She was prescribed outpatient COVID-19 treatment of azithromycin, vitamins D and C, and then quarantined for 2 weeks. Bookshelf doi: 10.1111/ijd.15700, 4. Background: After introducing Covid-19 vaccines, a few side effects were reported, pityriasis rosea being one of them.Therefore, this study will systematically review its manifestation afteradministration.Methods: Databases were searched, covering a timeline from December 1, 2019 to February 28, 2022.Data were independently extracted and accessed for bias. doi: 10.1111/dth.15602. J Eur Acad Dermatol Venereol 2016; 30: 544-545. Marcantonio-Santa Cruz OY, Vidal-Navarro Y, Pesqu D, et al.. Pityriasis rosea developing after COVID-19 vaccination. HHS Vulnerability Disclosure, Help Pityriasis rosea, pityriasis rosea-like eruptions, and herpes zoster in the setting of COVID-19 and COVID-19 vaccination. The first sign of pityriasis rosea is often one large patch on the skin, which is followed smaller patches or bumps. 2022 Jun;7:164-168. doi: 10.1016/j.jdin.2022.01.009. Origin, transmission, diagnosis and management of coronavirus disease 2019 (COVID19). In one small study, a majority of women who got pityriasis rosea in . Drago F, Ciccarese G, Javor S, Parodi A. Vaccine-induced pityriasis rosea and pityriasis rosea-like eruptions: a review of the literature. Leerunyakul K, Pakornphadungsit K, Suchonwanit P. Case report: pityriasis rosea-like eruption following COVID- 19 vaccination. The patients/participants provided their written informed consent to participate in this study. PR 12.7 days (mean) after the vaccination (19 patients after the 1. Clipboard, Search History, and several other advanced features are temporarily unavailable. Unable to load your collection due to an error, Unable to load your delegates due to an error. Cases of EM was observed after mRNA-based COVID-19 vaccines, and after CoronaVac vaccination wich is is an inactivated SARS-CoV-2 virus [13, 14]. SV, CAM, MC, VB, collected the data. The disease begins with a single erythematous plaque, the so-called herald patch that usually appears on the trunk: it is roundish, pink to red in color and remains the only clinical manifestation for some days, when widespread, clinically similar, although smaller lesions appear. Unable to load your collection due to an error, Unable to load your delegates due to an error. Environ Sci Pollut Res. J Formos Med Assoc. Br J Dermatol. Would you like email updates of new search results? Department of Pathophysiology and Transplantation, Universit degli Studi, Foundation IRCCS Ca Granda Ospedale Maggiore Policlinico, Via Pace 9, 20122 Milan, Italy. JAAD Case Rep. 2021;7:9394. (2021) 35:e5468. . J Am Acad Dermatol. Khan I, Elsanousi AA, Shareef AM, Tebha SS, Arif A, Gul S. Immun Inflamm Dis. Sprinkle bath water with an oatmeal-based bath product (Aveeno). Unfortunately, due to her deteriorating neurologic status, her associated symptoms were not evaluated properly. and transmitted securely. 2021;35(8):e489e491. . Please enable it to take advantage of the complete set of features! A spectrum of cutaneous reactions to SARs-CoV-2 (COVID-19) vaccines have been reported in the literature. PMC The latter is found in a younger age group. Disclaimer. PMC Bookshelf sharing sensitive information, make sure youre on a federal The https:// ensures that you are connecting to the Histopathologic features: (B) microscopic image at a low power field showing psoriasiform epidermal hyperplasia, perivascular infiltration, and interface dermatitis (hematoxylin-eosin; scale bar represents 100 m); (C) microscopic image at a high power field showing focal spongiotic dermatitis, interface dermatitis, and perivascular infiltration of lymphocytes and eosinophils (hematoxylin-eosin; scale bar represents 40 m). The association between pityriasis rosea and pityriasis rosea-like eruptions after Covid-19 vaccines was established, but given the scarcity of studies, there is a need to conduct different clinical trials to confirm this association further and study the etiology and mechanism of the disease. doi: 10.1111/dth.13650, 7. eCollection 2023 Mar 7. J Am Acad Dermatol. KL drafted the original manuscript. Pityriasis rosea developing after COVID-19 vaccination. 8600 Rockville Pike Before . Gianotti-Crosti Syndrome is a rare skin disease affecting children at the first years of age. Clipboard, Search History, and several other advanced features are temporarily unavailable. Clinical manifestations and histopathologic findings of reported patients with pityriasis-rosea like eruptions following COVID-19 vaccination. Bethesda, MD 20894, Web Policies Federal government websites often end in .gov or .mil. (2017) 5:20311. government site. However, after 14 days, she developed multiple discrete blanching erythematous oval patches and plaques on the lower abdomen, back, and bilateral upper thighs (Figures 1A,B). Before Postgrad Med J. We study 2,437 people who have Abdominal fullness prematurely after meals or Pityriasis rosea. Manifestation of pityriasis rosea and pityriasis rosea-like eruptions after Covid-19 vaccine: A systematic review. "Covid arm," a red, rashlike skin reaction that can occur at the injection site days after inoculation, has been well-publicized. doi: 10.1111/dth.15391. tivation is associated with pityriasis rosea-like eruption.6 Our cases of herpes simplex and pityriasis rosea-like eruption occurred in male patients following the first dose of BioNTech, whereas one female patient suffered herpes zoster following the third dose of CoronaVac. The cause of pityriasis rosea is not known, but it is commonly believed to be caused by a virus or bacteria. HHS Vulnerability Disclosure, Help Cyrenne BM, Al-Mohammedi F, DeKoven JG, Alhusayen R. J Eur Acad Dermatol Venereol. eCollection 2023 Mar 7. Moreover, almost all lesions faded with associated post-inflammatory hyperpigmentation (Figure 2B). Qaderi K, Golezar MH, Mardani A, Mallah MA, Moradi B, Kavoussi H, Shamsabadi A, Golezar S. Dermatol Ther. An official website of the United States government. The rash typically lasts 6-9 weeks, rarely extending longer than 12 weeks. Learning points: 8600 Rockville Pike 2021;85(1):4655. eCollection 2022. Oral baricitinib for moderate to severe alopecia areata in adolescents . A history of viral infection preceding the disease was reported But some patients also are developing delayed skin reactions on. Drago F, Ciccarese G, Parodi A. Pityriasis rosea and pityriasis rosea-like eruptions: How to distinguish them? Dermatol Ther. doi: 10.1111/jdv.17316, PubMed Abstract | CrossRef Full Text | Google Scholar, 2. As a library, NLM provides access to scientific literature. Temiz SA, Abdelmaksoud A, Dursun R, Durmaz K, Sadoughifar R, Hasan A. J Cosmet Dermatol. We present two cases of COVID-19 vaccine-induced pityriasis rosea. Involvement of the oral mucosa has also been reported in as many as 50% of all cases (11). Pityriasis rosea is a type of skin rash. All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers.